Thanks again, Goran!
After some trying I have my hardware issues resolved and the plane seems to be working fine.
I saw that the TBM had its own hardware profile, either natively or I created it myself. Activating my current user profile fixed the problem. Sorry, my own mistake!
(I had moved flight controls around since last using the TBM and had distributed functions differently. Saitek Pro Flight rudder pedals and yoke are also involved, as well as the Logitech Extreme 3D Pro joystick for some functions, particularily to replace the Saitek Throttle Quadrant, since it has a broken PS2 connection to the yoke.)