I see a potential problem. 16GB RAM, and you have a LOT of plugins installed. Plugins chew up a lot of RAM. Removing LiveTraffic just lightened the load on the RAM and that's why you didn't get a crash until much later in the flight, likely when you may have been approaching some dense scenery. Do you have a lot of orthoscenery installed? Are your settings dialled up very high?
As a test, remove half your plugins, preferably ones that you don't use very often, and then try again. Just make sure you leave Gizmo in there.