This can happen in any aircraft if you have X-Plane's random failures enabled. If it was/is the case, then you can also fix it "on the fly" by clicking on "fix all systems" (or similar) in the failures menu.
You could do the famous United flight 154 a.k.a. the "Island Hopper". If you read the Airways magazine, there is a very nice article on it in the current issue.
United flies it with a 738, but anyway... the route goes HNL-MAJ-KWA-KSA-PNI-TKK-GUM.
http://onemileatatime.boardingarea.com/2016/12/28/united-island-hopper-alaska-milk-run/