This is a pretty big one. During a brief flight KEYW-MWCR, shortly after reaching T/D, I looked at the FMC to insert an arrival (GORAN3, VOR approach rwy 08). The FMC would not react in any way to any button I pushed (page selection, prev/next, keyboard). It was on the LEGS page at the time and showing direct TADPO, which I had selected straight after takeoff. I tried changing the map range and it switched to showing me almost on top of UCL, way past the south coast of Cuba and 15 minutes past TADPO. At the same time the FMC switched to the DEP/ARR page, which I had tried to select previously. Basically what I figured out was that the PFD, MFD, and FMC were all completely frozen, and only updated once I touched something on the MFD control panel. This could be the range, mode, brightness... anything that makes the little MFD pop up in the bottom left hand corner of the screen would update the PDF, MFD, and FMC. All the background processes were working though: the aircraft followed the route, descended at the correct point, decelerated at 10,000 feet, etc.
I was able to input an arrival by pressing one key at a time and updating the FMC by changing the map range every time. At some point I noticed that if I kept holding the range selector (or brightness selector or any other MFD control) with the cursor to keep the popup map up, that would actually move and show everything properly. Basically I used a combination of standby instruments (as the PFD was also frozen), VOR DME and a visual approach to land at MWCR.
I'm on mac, so it can't be anything to do with that Windows Defender problem. After closing x-plane I checked the log.txt, and beginning at around 48 minutes into the session (the flight took 58 minutes, so the whole session was probably around an hour and a half as I spent some time on the ground at KEYW before taking off) there are a few hundred lines of 'no such error' readouts produced by the JAR Design ground handling plugin. These continue until the end of the session. There is nothing else in the log.txt after the first 'no such error' message appears except for hundreds of lines of the same thing.
This was fine due to the short nature of the flight, but I can predict that on longer flights such a freeze of the PFD, MFD, and FMC would make continuing the flight very difficult. If this was somehow caused by ground handling, that's a pretty big deal, as its highly likely that people using the 733 also have that plugin installed.