During my flight from CYUL to KDAL, my IRS unaligned shortly after I got to cruise, causing my map to go blank and default to ROLL on the autopilot. I looked for the issue in the discord, found where I can automatically realign it by Challenger 650 > Study > INS > Align IRS, did that then about 10-15 seconds later, they unaligned again.
For additional information, I am running Active Sky and I noticed that it happened when my weather refreshed, don't know if that's a contributing factor or not.