After reading that other thread I did a full scan on my main windows drive and found no errors to fix. I'm only running two monitors as well. I had the same issue just switching to one monitor.
I ended up installing a fresh copy of XP11 on a new drive. After installing the TBM as the only 3rd party content I was able to do a quick test flight with a full shutdown and tie down of the plane. I did one more test and quit the simulator mid flight. I was able to say no on the resume flight windows the next time and not CTD. This looks promising but I will start adding the plugins one by one to see if they had any effect.